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ALPPS vs. Two-Stage Hepatectomy RCT

Welcome to the "ALPPS vs. TSH for CRLM" - RCT Platform!

Associating Liver Partition with Portal vein ligation for Staged hepatectomy (ALPPS) versus Two-Stage Hepatectomy (TSH) for marginally resectable colorectal liver metastases – a multicentric, randomized controlled trial.

Short title: "ALPPS vs. TSH for CRLM" - RCT NCT02758977
SNCTP: TBA (Register of clinical trials in Switzerland)
KEK-ZH Nr.: 2015-0024 (Local swiss ethics committee/IRB number)


Sponsor-Investigator/Principal Investigator:

Prof. Pierre-Alain Clavien, MD, PhD, FACS
Department of Visceral and Transplantation Surgery
University Hospital Zurich
Raemistrasse 100
CH-8091 Zurich
Phone: +41 (0)44 255 33 00
Fax: +41 (0)44 255 44 49


This multi-institutional trial is open to all centers participating in the registry who have included a minimum of 5 cases.

Further information is provided under the following links. 

Please use the contact forms if you should have any further questions or are interested in participation.




Zurich, the 17th April 2016

The department of visceral- & transplantation surgery at the university hospital of Zurich is glad to announce, that approval of the local Cantonal Ethics Committee (KEK) / Institutional Review Board (IRB) was finally obtaind in February 2016 for our "ALPPS vs. TSH for CRLM" - RCT.

Preparations for the start of the study are currently under way, patient inclusion in our department starts from 1st of May 2016.





University Hospital Zurich
Department of Surgery
Raemistrasse 100
8091 Zurich, Switzerland


Phone: +41 (0)44 255 33 00
Fax:     +41 (0)44 255 44 49